The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).

Journal Article (Journal Article)

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

Full Text

Duke Authors

Cited Authors

  • Kraan, MC; Patel, DD; Haringman, JJ; Smith, MD; Weedon, H; Ahern, MJ; Breedveld, FC; Tak, PP

Published Date

  • 2001

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 65 - 71

PubMed ID

  • 11178128

Pubmed Central ID

  • PMC17826

International Standard Serial Number (ISSN)

  • 1465-9905

Digital Object Identifier (DOI)

  • 10.1186/ar141


  • eng

Conference Location

  • England