The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion.

Journal Article (Journal Article)

Identification of regulatory molecules that determine the extent and direction of expansion is necessary to understand how cell morphogenesis is controlled in plants. We recently identified COB (COBRA) as a key regulator of the orientation of cell expansion in the root. Analysis of the Arabidopsis genome sequence indicated that COB belongs to a multigene family consisting of 12 members, all predicted to encode glycosylphosphatidylinositol-anchored proteins. All but two of the COBL (COB-like) genes are expressed in most organs examined, suggesting possible redundancy. Sequence comparisons, phylogenetic analyses, and exon-intron positions revealed that the COB family is composed of two main subgroups sharing a common architecture, one subgroup being characterized by an additional N-terminal domain. Identification of expressed sequence tags corresponding to potential orthologs in other plant species suggested that COB-related functions are required in all vascular plants. Together, these results indicate that COB family members are likely to be important new players at the plasma membrane-cell wall interface.

Full Text

Duke Authors

Cited Authors

  • Roudier, F; Schindelman, G; DeSalle, R; Benfey, PN

Published Date

  • October 2002

Published In

Volume / Issue

  • 130 / 2

Start / End Page

  • 538 - 548

PubMed ID

  • 12376623

Pubmed Central ID

  • PMC166585

Electronic International Standard Serial Number (EISSN)

  • 1532-2548

International Standard Serial Number (ISSN)

  • 0032-0889

Digital Object Identifier (DOI)

  • 10.1104/pp.007468


  • eng