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Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.

Publication ,  Journal Article
Mahrholdt, H; Wagner, A; Holly, TA; Elliott, MD; Bonow, RO; Kim, RJ; Judd, RM
Published in: Circulation
October 29, 2002

BACKGROUND: The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT). METHODS AND RESULTS: Patients with chronic myocardial infarction defined by enzymes (peak creatine kinase-MB 173+/-119 U/L) were scanned twice by MRI (MRI I and MRI II, n=20) and twice by SPECT (SPECT I and SPECT II, n=15) on the same day. The MRI contrast agent was injected during MRI I but not MRI II to test the effect of imaging time after contrast. Resting Tc-MIBI SPECT images were acquired and infarct size was determined with commercial software. Infarct size in patients scanned by MRI and SPECT was 14+/-6% of left ventricular mass (%LV) by MRI (range 4%LV to 27%LV) and 14+/-7%LV by SPECT (range 4%LV to 26%LV). MRI I and II scans were performed 10+/-2 and 27+/-3 minutes after contrast, respectively. For MRI, the difference in infarct size between scans I and II (bias) was -0.1%LV, and the coefficient of repeatability was +/-2.4%LV. For SPECT, bias was -1.3%LV, and the coefficient of repeatability was +/-4.0%LV. Within individual patients, no systematic differences in infarct size were detected when the 2 MRI scans were compared, the 2 SPECT scans were compared, or MRI was compared to SPECT. CONCLUSION: The size of healed infarcts measured by contrast-enhanced MRI does not change between 10 and 30 minutes after contrast. The clinical reproducibility of contrast-enhanced MRI for infarct size determination compares favorably with that of routine clinical SPECT.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 29, 2002

Volume

106

Issue

18

Start / End Page

2322 / 2327

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Time Factors
  • Technetium Tc 99m Sestamibi
  • Reproducibility of Results
  • Prospective Studies
  • Predictive Value of Tests
  • Myocardial Infarction
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Enhancement
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mahrholdt, H., Wagner, A., Holly, T. A., Elliott, M. D., Bonow, R. O., Kim, R. J., & Judd, R. M. (2002). Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation, 106(18), 2322–2327. https://doi.org/10.1161/01.cir.0000036368.63317.1c
Mahrholdt, Heiko, Anja Wagner, Thomas A. Holly, Michael D. Elliott, Robert O. Bonow, Raymond J. Kim, and Robert M. Judd. “Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.Circulation 106, no. 18 (October 29, 2002): 2322–27. https://doi.org/10.1161/01.cir.0000036368.63317.1c.
Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, et al. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation. 2002 Oct 29;106(18):2322–7.
Mahrholdt, Heiko, et al. “Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.Circulation, vol. 106, no. 18, Oct. 2002, pp. 2322–27. Pubmed, doi:10.1161/01.cir.0000036368.63317.1c.
Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, Judd RM. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation. 2002 Oct 29;106(18):2322–2327.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 29, 2002

Volume

106

Issue

18

Start / End Page

2322 / 2327

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Time Factors
  • Technetium Tc 99m Sestamibi
  • Reproducibility of Results
  • Prospective Studies
  • Predictive Value of Tests
  • Myocardial Infarction
  • Middle Aged
  • Magnetic Resonance Imaging
  • Image Enhancement