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Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury.

Publication ,  Journal Article
Rehwald, WG; Fieno, DS; Chen, E-L; Kim, RJ; Judd, RM
Published in: Circulation
January 15, 2002

BACKGROUND: Discrepant reports have been published recently regarding the relationship of contrast-enhanced magnetic resonance image intensities to reversible and irreversible ischemic injury. Unlike image intensities, contrast agent concentrations provide data independent of the MRI technique. We used electron probe x-ray microanalysis (EPXMA) to simultaneously examine concentrations of Gd, Na, P, S, Cl, K, and Ca over a range of myocardial injuries. Methods and Results- Reversible and irreversible injury were studied in 38 rabbits divided into 4 groups defined by occlusion and reperfusion time, as well as time the animals were euthanized. Gd-DTPA was administered, and the hearts were excised and rapidly frozen, cryosectioned, freeze-dried, and examined by EPXMA in up to 3 regions: remote, infarcted, and at risk but not infarcted. Infarcted regions were defined by anti-myoglobin antibody or triphenyltetrazolium chloride staining. Regions at risk were defined by fluorescent microparticles administered during occlusion. Compared with remote regions, in acutely infarcted regions, Gd was increased (235+/-24%, P<0.005) in the same 50 x 100-microm areas in which Na was increased (154+/-5%, P<0.001) and K was decreased (52+/-8%, P<0.001). Similarly, in chronically infarcted regions, Gd was increased (472+/-78%, P<0.001) in areas in which Na was increased (332+/-28%, P<0.001) and K was decreased (47+/-5%, P<0.001). Also compared with remote regions, however, concentrations of Gd, Na, and K were not elevated after reperfusion in regions that were at risk but not infarcted (P=NS). CONCLUSIONS: Regional elevations in myocardial MRI contrast agent concentrations are exclusively associated with irreversible ischemic injury defined histologically and by regional electrolyte concentrations.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 15, 2002

Volume

105

Issue

2

Start / End Page

224 / 229

Location

United States

Related Subject Headings

  • Sulfur
  • Sodium
  • Radiography
  • Rabbits
  • Potassium
  • Phosphorus
  • Myocardium
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Kinetics
 

Citation

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ICMJE
MLA
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Rehwald, W. G., Fieno, D. S., Chen, E.-L., Kim, R. J., & Judd, R. M. (2002). Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation, 105(2), 224–229. https://doi.org/10.1161/hc0202.102016
Rehwald, Wolfgang G., David S. Fieno, Enn-Ling Chen, Raymond J. Kim, and Robert M. Judd. “Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury.Circulation 105, no. 2 (January 15, 2002): 224–29. https://doi.org/10.1161/hc0202.102016.
Rehwald WG, Fieno DS, Chen E-L, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002 Jan 15;105(2):224–9.
Rehwald, Wolfgang G., et al. “Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury.Circulation, vol. 105, no. 2, Jan. 2002, pp. 224–29. Pubmed, doi:10.1161/hc0202.102016.
Rehwald WG, Fieno DS, Chen E-L, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002 Jan 15;105(2):224–229.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 15, 2002

Volume

105

Issue

2

Start / End Page

224 / 229

Location

United States

Related Subject Headings

  • Sulfur
  • Sodium
  • Radiography
  • Rabbits
  • Potassium
  • Phosphorus
  • Myocardium
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Kinetics