Skip to main content

Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging.

Publication ,  Journal Article
Hillenbrand, HB; Kim, RJ; Parker, MA; Fieno, DS; Judd, RM
Published in: Circulation
October 3, 2000

BACKGROUND: Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early after myocardial infarction, indexes myocardial salvage. We studied the relationship between the transmural extent of hyperenhancement by contrast-enhanced MRI, restoration of flow, and recovery of function. METHODS AND RESULTS: The left anterior descending coronary artery was occluded in dogs (n=15) for either 45 minutes, 90 minutes, or permanently. Cine and contrast-enhanced MRI were performed 3 days after the procedure; cine MRI was also done 10 and 28 days after the procedure. The transmural extent of hyperenhancement and wall thickening were determined using a 60-segment model. The mean transmural extent of hyperenhancement for the 45-minute occlusion group was 22% of the 90-minute group and 18% of the permanent occlusion group (P:<0.05 for both). The transmural extent of hyperenhancement on day 3 was related to future improvement in both wall thickening score and absolute wall thickening at 10 and 28 days (P:<0.0001 for each). For example, of the 415 segments on day 3 that were dysfunctional and had <25% transmural hyperenhancement, 362 (87%) improved by day 28. Conversely, no segments (0 of 9) with 100% hyperenhancement improved. The transmural extent of hyperenhancement on day 3 was a better predictor of improvement in contractile function than occlusion time (P:<0.0001). CONCLUSIONS: A reduction in the transmural extent of hyperenhancement by contrast-enhanced MRI early after myocardial infarction is associated with an early restoration of flow and future improvement in contractile function.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 3, 2000

Volume

102

Issue

14

Start / End Page

1678 / 1683

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Dogs
  • Coronary Circulation
  • Contrast Media
  • Cardiovascular System & Hematology
  • Animals
  • Acute Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hillenbrand, H. B., Kim, R. J., Parker, M. A., Fieno, D. S., & Judd, R. M. (2000). Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging. Circulation, 102(14), 1678–1683. https://doi.org/10.1161/01.cir.102.14.1678
Hillenbrand, H. B., R. J. Kim, M. A. Parker, D. S. Fieno, and R. M. Judd. “Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging.Circulation 102, no. 14 (October 3, 2000): 1678–83. https://doi.org/10.1161/01.cir.102.14.1678.
Hillenbrand HB, Kim RJ, Parker MA, Fieno DS, Judd RM. Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging. Circulation. 2000 Oct 3;102(14):1678–83.
Hillenbrand, H. B., et al. “Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging.Circulation, vol. 102, no. 14, Oct. 2000, pp. 1678–83. Pubmed, doi:10.1161/01.cir.102.14.1678.
Hillenbrand HB, Kim RJ, Parker MA, Fieno DS, Judd RM. Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging. Circulation. 2000 Oct 3;102(14):1678–1683.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 3, 2000

Volume

102

Issue

14

Start / End Page

1678 / 1683

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Dogs
  • Coronary Circulation
  • Contrast Media
  • Cardiovascular System & Hematology
  • Animals
  • Acute Disease