Pharmacokinetics of single doses of gentamicin given intravenously and intramuscularly to turkeys.

Published

Journal Article

The disposition and absorption kinetics of gentamicin were studied in healthy, mature male and female turkeys (n = 10). Single doses of gentamicin (5 mg/kg) were injected either i.v. or i.m. with a 30-day rest period between each treatment. Baseline and serial venous blood samples (n = 17) were collected from each turkey. Serum concentrations of gentamicin were determined in duplicate for 24 h after each treatment, using radio-immunoassay. Using nonlinear least-square regression methods, the combined data of the i.v. and i.m. treatments were best described by a two-compartment open model. Kinetic analysis of the data after a single i.v. dose provided the following mean values: t1/2 alpha = 0.170 +/- 0.093 h, t1/2 beta = 2.57 +/- 0.79 h, MRT = 3.62 +/- 0.96 h, Vc = 0.090 +/- 0.017 l/kg, Vd(ss) = 0.172 +/- 0.024 l/kg, Vd(area) = 0.190 +/- 0.030 l/kg, and Clt = 49.8 +/- 9.8 ml/h/kg. After a single i.m. dose, the following mean values were determined: MRT = 5.10 +/- 1.73 h, t1/2abs = 0.74 +/- 0.66 h, tlag = 0.07 +/- 0.19 h, Clt/F = 50.7 +/- 12.5 ml/h/kg, Vd(area)/F = 0.193 +/- 0.044 l/kg, and F = 102 +/- 21%. Kinetic calculations made with the single i.m. data predicted that an i.m. injection of gentamicin at the dosage rate of 3 mg/kg q. every 12 h would provide average steady state serum concentrations of 4.93 micrograms/ml.

Full Text

Cited Authors

  • Pedersoli, WM; Ravis, WR; Askins, DR; Krista, LM; Spano, JS; Whitesides, JF; Tolbert, DS

Published Date

  • June 1989

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 124 - 132

PubMed ID

  • 2746719

Pubmed Central ID

  • 2746719

Electronic International Standard Serial Number (EISSN)

  • 1365-2885

International Standard Serial Number (ISSN)

  • 0140-7783

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2885.1989.tb00653.x

Language

  • eng