Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.

Journal Article (Journal Article)

We studied two children with recurrent cancer, who during treatment with ifosfamide developed severe encephalopathy characterized by coma of several days duration. Ifosfamide was used as a single drug without mesna as an uroprotector. A 1-hour infusion of ifosfamide (1.8 g/m2) was given on days one and two of a planned 5-day course. Encephalopathy was associated with severe electroencephalographic abnormalities, e.g. slowing in delta range in one patient and electrographic seizures in another. Both, clinical and electroencephalographic features of encephalopathy were reversible.

Full Text

Duke Authors

Cited Authors

  • Gieron, MA; Barak, LS; Estrada, J

Published Date

  • 1988

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 29 - 30

PubMed ID

  • 2840485

International Standard Serial Number (ISSN)

  • 0167-594X

Digital Object Identifier (DOI)

  • 10.1007/BF00163537


  • eng

Conference Location

  • United States