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Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.

Publication ,  Journal Article
Gieron, MA; Barak, LS; Estrada, J
Published in: J Neurooncol
1988

We studied two children with recurrent cancer, who during treatment with ifosfamide developed severe encephalopathy characterized by coma of several days duration. Ifosfamide was used as a single drug without mesna as an uroprotector. A 1-hour infusion of ifosfamide (1.8 g/m2) was given on days one and two of a planned 5-day course. Encephalopathy was associated with severe electroencephalographic abnormalities, e.g. slowing in delta range in one patient and electrographic seizures in another. Both, clinical and electroencephalographic features of encephalopathy were reversible.

Duke Scholars

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

1988

Volume

6

Issue

1

Start / End Page

29 / 30

Location

United States

Related Subject Headings

  • Wilms Tumor
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Male
  • Kidney Neoplasms
  • Ifosfamide
  • Humans
  • Female
  • Electroencephalography
  • Coma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gieron, M. A., Barak, L. S., & Estrada, J. (1988). Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors. J Neurooncol, 6(1), 29–30. https://doi.org/10.1007/BF00163537
Gieron, M. A., L. S. Barak, and J. Estrada. “Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.J Neurooncol 6, no. 1 (1988): 29–30. https://doi.org/10.1007/BF00163537.
Gieron, M. A., et al. “Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.J Neurooncol, vol. 6, no. 1, 1988, pp. 29–30. Pubmed, doi:10.1007/BF00163537.
Journal cover image

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

1988

Volume

6

Issue

1

Start / End Page

29 / 30

Location

United States

Related Subject Headings

  • Wilms Tumor
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Male
  • Kidney Neoplasms
  • Ifosfamide
  • Humans
  • Female
  • Electroencephalography
  • Coma