Molecular genetics: toward an understanding of childhood cancer.

Journal Article (Review)

Investigation in cellular and molecular genetics has yielded a wealth of new information regarding the role of genetic alterations in the etiology of childhood cancer. The recent advancement of molecular biologic techniques has allowed researchers to bridge the gap from the description of chromosomal aberrations in tumor cells to the current identification of oncogenes and tumor suppressor genes involved in malignant transformation. This article reviews the advances in molecular genetics of childhood cancer, briefly outlines the history, and details the current knowledge of the use of cytogenetics, oncogenes, and other tools in the diagnosis, management, and further understanding of pediatric malignancies.

Full Text

Duke Authors

Cited Authors

  • Kreissman, SG

Published Date

  • February 1993

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 2 - 10

PubMed ID

  • 8062019

International Standard Serial Number (ISSN)

  • 1055-8586

Language

  • eng

Conference Location

  • United States