Skip to main content
Journal cover image

Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes.

Publication ,  Journal Article
O'Hara, SM; Frush, DP; Babcock, DS; Lewis, AG; Barr, LL; Bukowski, TP; Kline-Fath, BM; Sheldon, CA
Published in: Acad Radiol
April 1996

RATIONALE AND OBJECTIVES: We examined whether the intravenous (IV) Doppler ultrasound contrast agent SHU 508 would improve the detection of reduced perfusion of rabbit testes when normal flow was otherwise difficult to detect. METHODS: Seventeen anesthetized prepubertal rabbits underwent random unilateral spermatic cord ligation and a contralateral sham operation. Immediate, blinded, and systematic color Doppler examination of each pair of testes was recorded before and after IV administration of 1 ml (300 mg) SHU 508, a gas-containing microparticle. Recorded examinations were reviewed by two pediatric radiologists who were unaware of experimental conditions and who graded intratesticular flow. RESULTS: For 34 pairs of observations (17 animals x 2 observers), intratesticular flow was absent in the sham-operated testes in 18 precontrast and two postcontrast images. The false-positive rate in this group decreased from 53% to 6%. This improvement in the detection of normal blood flow was statistically significant. The absence of flow in the ischemic testis was not significantly different before or after contrast agent administration. CONCLUSION: IV SHU 508 enhances color Doppler ultrasound detection of flow not otherwise evident in prepubertal rabbit testes. Doppler ultrasound contrast agents may be used in a setting of suspected torsion when routine Doppler sonography is indeterminate.

Duke Scholars

Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

April 1996

Volume

3

Issue

4

Start / End Page

319 / 324

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Color
  • Testis
  • Sensitivity and Specificity
  • Reperfusion
  • Regional Blood Flow
  • Rabbits
  • Polysaccharides
  • Nuclear Medicine & Medical Imaging
  • Male
  • Ischemia
 

Citation

APA
Chicago
ICMJE
MLA
NLM
O’Hara, S. M., Frush, D. P., Babcock, D. S., Lewis, A. G., Barr, L. L., Bukowski, T. P., … Sheldon, C. A. (1996). Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes. Acad Radiol, 3(4), 319–324. https://doi.org/10.1016/s1076-6332(96)80249-2
O’Hara, S. M., D. P. Frush, D. S. Babcock, A. G. Lewis, L. L. Barr, T. P. Bukowski, B. M. Kline-Fath, and C. A. Sheldon. “Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes.Acad Radiol 3, no. 4 (April 1996): 319–24. https://doi.org/10.1016/s1076-6332(96)80249-2.
O’Hara SM, Frush DP, Babcock DS, Lewis AG, Barr LL, Bukowski TP, et al. Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes. Acad Radiol. 1996 Apr;3(4):319–24.
O’Hara, S. M., et al. “Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes.Acad Radiol, vol. 3, no. 4, Apr. 1996, pp. 319–24. Pubmed, doi:10.1016/s1076-6332(96)80249-2.
O’Hara SM, Frush DP, Babcock DS, Lewis AG, Barr LL, Bukowski TP, Kline-Fath BM, Sheldon CA. Doppler contrast sonography for detecting reduced perfusion in experimental ischemia of prepubertal rabbit testes. Acad Radiol. 1996 Apr;3(4):319–324.
Journal cover image

Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

April 1996

Volume

3

Issue

4

Start / End Page

319 / 324

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Color
  • Testis
  • Sensitivity and Specificity
  • Reperfusion
  • Regional Blood Flow
  • Rabbits
  • Polysaccharides
  • Nuclear Medicine & Medical Imaging
  • Male
  • Ischemia