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Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.

Publication ,  Journal Article
Frush, DP; McNamara, JO
Published in: Exp Neurol
April 1986

We studied the occurrence of wet dog shakes during the evolution of kindling induced by electrical stimulation of the lateral entorhinal cortex. Wet dog shakes occur with high incidence, particularly early in development of kindling. We also demonstrated that microinjection of colchicine into the hippocampus, but not into neocortex, produced a 95% suppression of wet dog shakes. We propose that the suppressive effect of colchicine is mediated by destruction of dentate granule cells. Together with evidence from other investigations, these data support the idea that activation of hippocampal neurons is essential for production of wet dog shakes induced by stimulation of the limbic system.

Duke Scholars

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

April 1986

Volume

92

Issue

1

Start / End Page

102 / 113

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Kindling, Neurologic
  • Hippocampus
  • Colchicine
  • Cerebellar Nuclei
  • Behavior, Animal
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Frush, D. P., & McNamara, J. O. (1986). Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. Exp Neurol, 92(1), 102–113. https://doi.org/10.1016/0014-4886(86)90128-7
Frush, D. P., and J. O. McNamara. “Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.Exp Neurol 92, no. 1 (April 1986): 102–13. https://doi.org/10.1016/0014-4886(86)90128-7.
Frush, D. P., and J. O. McNamara. “Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.Exp Neurol, vol. 92, no. 1, Apr. 1986, pp. 102–13. Pubmed, doi:10.1016/0014-4886(86)90128-7.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

April 1986

Volume

92

Issue

1

Start / End Page

102 / 113

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Kindling, Neurologic
  • Hippocampus
  • Colchicine
  • Cerebellar Nuclei
  • Behavior, Animal
  • Animals