Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.

Journal Article

We studied the occurrence of wet dog shakes during the evolution of kindling induced by electrical stimulation of the lateral entorhinal cortex. Wet dog shakes occur with high incidence, particularly early in development of kindling. We also demonstrated that microinjection of colchicine into the hippocampus, but not into neocortex, produced a 95% suppression of wet dog shakes. We propose that the suppressive effect of colchicine is mediated by destruction of dentate granule cells. Together with evidence from other investigations, these data support the idea that activation of hippocampal neurons is essential for production of wet dog shakes induced by stimulation of the limbic system.

Full Text

Duke Authors

Cited Authors

  • Frush, DP; McNamara, JO

Published Date

  • April 1986

Published In

Volume / Issue

  • 92 / 1

Start / End Page

  • 102 - 113

PubMed ID

  • 3956642

Pubmed Central ID

  • 3956642

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/0014-4886(86)90128-7


  • eng

Conference Location

  • United States