Evidence implicating dentate granule cells in development of entorhinal kindling.

Journal Article (Journal Article)

Kindling is an animal model of epilepsy induced by periodic focal electrical stimulation of the brain. The network of brain structures responsible for this permanent abnormal excitability is unknown. We hypothesized that the hippocampal formation serves a facilitatory role in lateral entorhinal cortex kindling. We therefore investigated the effect of dentate granule cell destruction induced by the neurotoxin, colchicine into entorhinal cortex kindling development. We found that injection of colchicine into the hippocampal formation, but not frontal cortex, resulted in a 31% increase in the number of stimulations required to establish kindling in comparison with vehicle-injected controls. The effect of intrahippocampal colchicine was due to a 95% increase in the number of stimulations required to attain a class 2 seizure. Based on these and other data, we propose that elimination of granule cells reduces activation of CA2/3 neurons, thereby impairing development of entorhinal kindling.

Full Text

Duke Authors

Cited Authors

  • Frush, DP; Giacchino, JL; McNamara, JO

Published Date

  • April 1986

Published In

Volume / Issue

  • 92 / 1

Start / End Page

  • 92 - 101

PubMed ID

  • 3956661

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/0014-4886(86)90127-5


  • eng

Conference Location

  • United States