Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve.


Journal Article

Nerve growth factor (NGF), in addition to its well-known effects as a soluble neurite growth-promoting factor, also appears to promote the elongation of neurites when it is adsorbed to tissue culture substrates. Peripheral nerve Schwann cells appear to possess a receptor for NGF on their surfaces which is induced substantially after axotomy. We have found that the adsorption of NGF onto cryostat sections of the distal stump of previously severed sciatic nerve enhances neurite growth over this tissue. This finding, coupled with the two previous observations, suggests that Schwann cell surface NGF receptors serve to bind to NGF-like growth factors so as to provide favorable surfaces for regenerating peripheral nerve axons.

Full Text

Duke Authors

Cited Authors

  • Sandrock, AW; Matthew, WD

Published Date

  • November 10, 1987

Published In

Volume / Issue

  • 425 / 2

Start / End Page

  • 360 - 363

PubMed ID

  • 3427437

Pubmed Central ID

  • 3427437

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(87)90520-8


  • eng

Conference Location

  • Netherlands