CD9 plays a role in Schwann cell migration in vitro.

Published

Journal Article

To identify molecules that regulate Schwann cell migration, we have generated a panel of monoclonal antibodies against Schwann cell surface antigens that modulate Schwann cell migration in in vitro bioassays. One of these antibodies, SMRA1, recognizes a 26 kDa Schwann cell surface membrane protein identified here as CD9. SMRA1 enhances Schwann cell migration on two biologically relevant substrates: living axons of cultured dorsal root ganglion neurons, and cryostat sections of sciatic nerve. This CD9-induced regulation of Schwann cell motility is correlated with a rise in cytosolic calcium and enhanced tyrosine phosphorylation of several Schwann cell proteins. These results, together with the findings of Hadjiargyrou and Patterson (1994), implicate CD9 as an important regulator of Schwann cell behavior in peripheral nerve.

Full Text

Duke Authors

Cited Authors

  • Anton, ES; Hadjiargyrou, M; Patterson, PH; Matthew, WD

Published Date

  • January 1995

Published In

Volume / Issue

  • 15 / 1 Pt 2

Start / End Page

  • 584 - 595

PubMed ID

  • 7529830

Pubmed Central ID

  • 7529830

International Standard Serial Number (ISSN)

  • 0270-6474

Language

  • eng

Conference Location

  • United States