In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age.

Journal Article (Journal Article)

We used sagittal and coronal T1 weighted magnetic resonance images, at 1.5 Tesla, to measure the height, width, length, and cross-sectional area and to generate two estimates of pituitary gland volume in 35 normal volunteers aged 26-79 yr (19 females and 16 males). Subjects over 50 yr of age had significantly smaller pituitary gland height (P = 0.03), area (P = 0.04), and volume (P = 0.04) than those under 50 yr (by two-tailed t test). Overall, age was negatively correlated with pituitary volume (V1: r = -0.51; P = 0.003; V2: r = -0.47; P = 0.008), area (r = -0.43; P = 0.009), and height (r = -0.46; P = 0.005), but not with pituitary length or width. There were no statistically significant differences in pituitary size between men and women (by two-tailed t test). These findings suggest that pituitary gland height provides a good single measure for the assessment of pituitary gland size and that age must be controlled for in studies of pituitary gland size.

Full Text

Duke Authors

Cited Authors

  • Lurie, SN; Doraiswamy, PM; Husain, MM; Boyko, OB; Ellinwood, EH; Figiel, GS; Krishnan, KR

Published Date

  • August 1990

Published In

Volume / Issue

  • 71 / 2

Start / End Page

  • 505 - 508

PubMed ID

  • 2380345

International Standard Serial Number (ISSN)

  • 0021-972X

Digital Object Identifier (DOI)

  • 10.1210/jcem-71-2-505


  • eng

Conference Location

  • United States