Current status of antioxidant therapy for Alzheimer's Disease.

Journal Article (Journal Article;Review)

Accumulating evidence from preclinical and clinical studies supports the hypothesis that oxidative stress may be associated with the onset and progression of Alzheimer's Disease (AD). Antioxidant therapies are being promoted in the lay press to enhance mental functions and delay cognitive losses with aging. An increasing number of physicians are also recommending antioxidant therapies, such as high dose vitamin E, for subjects with AD and other neurodegenerative disorders. High dose vitamin E, ginkgo biloba, and selegiline are three putative antioxidants that have been tested in randomized multicenter trial conditions in the US. This paper summarizes the oxidative stress hypothesis of AD and reviews the strengths and limitations of published antioxidant studies in AD in relation to the role of such therapies in practice.

Full Text

Duke Authors

Cited Authors

  • Pitchumoni, SS; Doraiswamy, PM

Published Date

  • December 1998

Published In

Volume / Issue

  • 46 / 12

Start / End Page

  • 1566 - 1572

PubMed ID

  • 9848820

International Standard Serial Number (ISSN)

  • 0002-8614

Digital Object Identifier (DOI)

  • 10.1111/j.1532-5415.1998.tb01544.x


  • eng

Conference Location

  • United States