Neuroanatomical substrates of depression in the elderly.
Publication
, Journal Article
Krishnan, KR; McDonald, WM; Doraiswamy, PM; Tupler, LA; Husain, M; Boyko, OB; Figiel, GS; Ellinwood, EH
Published in: Eur Arch Psychiatry Clin Neurosci
1993
The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to have smaller caudate nuclei, smaller putaminal complexes and in increased frequency of subcortical hyperintensities compared with normal, healthy controls. These findings were more pronounced in patients with late-onset depression. Based on these findings, the authors discuss the role of the basal ganglia in the pathophysiology of depression in the elderly.
Duke Scholars
Published In
Eur Arch Psychiatry Clin Neurosci
DOI
ISSN
0940-1334
Publication Date
1993
Volume
243
Issue
1
Start / End Page
41 / 46
Location
Germany
Related Subject Headings
- Risk Factors
- Radiography
- Psychiatry
- Male
- Magnetic Resonance Imaging
- Hypertension
- Humans
- Female
- Depressive Disorder
- Basal Ganglia Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R., McDonald, W. M., Doraiswamy, P. M., Tupler, L. A., Husain, M., Boyko, O. B., … Ellinwood, E. H. (1993). Neuroanatomical substrates of depression in the elderly. Eur Arch Psychiatry Clin Neurosci, 243(1), 41–46. https://doi.org/10.1007/BF02191522
Krishnan, K. R., W. M. McDonald, P. M. Doraiswamy, L. A. Tupler, M. Husain, O. B. Boyko, G. S. Figiel, and E. H. Ellinwood. “Neuroanatomical substrates of depression in the elderly.” Eur Arch Psychiatry Clin Neurosci 243, no. 1 (1993): 41–46. https://doi.org/10.1007/BF02191522.
Krishnan KR, McDonald WM, Doraiswamy PM, Tupler LA, Husain M, Boyko OB, et al. Neuroanatomical substrates of depression in the elderly. Eur Arch Psychiatry Clin Neurosci. 1993;243(1):41–6.
Krishnan, K. R., et al. “Neuroanatomical substrates of depression in the elderly.” Eur Arch Psychiatry Clin Neurosci, vol. 243, no. 1, 1993, pp. 41–46. Pubmed, doi:10.1007/BF02191522.
Krishnan KR, McDonald WM, Doraiswamy PM, Tupler LA, Husain M, Boyko OB, Figiel GS, Ellinwood EH. Neuroanatomical substrates of depression in the elderly. Eur Arch Psychiatry Clin Neurosci. 1993;243(1):41–46.
Published In
Eur Arch Psychiatry Clin Neurosci
DOI
ISSN
0940-1334
Publication Date
1993
Volume
243
Issue
1
Start / End Page
41 / 46
Location
Germany
Related Subject Headings
- Risk Factors
- Radiography
- Psychiatry
- Male
- Magnetic Resonance Imaging
- Hypertension
- Humans
- Female
- Depressive Disorder
- Basal Ganglia Diseases