Neuroanatomical substrates of depression in the elderly.

Journal Article (Journal Article)

The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to have smaller caudate nuclei, smaller putaminal complexes and in increased frequency of subcortical hyperintensities compared with normal, healthy controls. These findings were more pronounced in patients with late-onset depression. Based on these findings, the authors discuss the role of the basal ganglia in the pathophysiology of depression in the elderly.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; McDonald, WM; Doraiswamy, PM; Tupler, LA; Husain, M; Boyko, OB; Figiel, GS; Ellinwood, EH

Published Date

  • 1993

Published In

Volume / Issue

  • 243 / 1

Start / End Page

  • 41 - 46

PubMed ID

  • 8399409

International Standard Serial Number (ISSN)

  • 0940-1334

Digital Object Identifier (DOI)

  • 10.1007/BF02191522


  • eng

Conference Location

  • Germany