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Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study.

Publication ,  Journal Article
Shah, SA; Doraiswamy, PM; Husain, MM; Escalona, PR; Na, C; Figiel, GS; Patterson, LJ; Ellinwood, EH; McDonald, WM; Boyko, OB
Published in: Acta Psychiatr Scand
June 1992

High-field magnetic resonance (MR) images were used to study posterior fossa morphology in 27 patients with major depression and 36 normal control subjects. Depressed patients demonstrated smaller brain stem and cerebellar vermis than controls. These differences were highly significant for the anterior cerebellar vermis and medulla. There was also a striking age-related decline in midbrain size in depressed patients as well as in controls. Our results are consistent with several lines of evidence implicating a role for the cerebellar vermis in affective disorders and, in addition, provide the first MR documentation of the differential effects of aging on posterior fossa morphology in normal subjects compared with patients with major depression.

Duke Scholars

Published In

Acta Psychiatr Scand

DOI

ISSN

0001-690X

Publication Date

June 1992

Volume

85

Issue

6

Start / End Page

474 / 479

Location

United States

Related Subject Headings

  • Psychiatry
  • Pons
  • Neurocognitive Disorders
  • Middle Aged
  • Medulla Oblongata
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Depressive Disorder
 

Citation

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ICMJE
MLA
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Shah, S. A., Doraiswamy, P. M., Husain, M. M., Escalona, P. R., Na, C., Figiel, G. S., … Boyko, O. B. (1992). Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study. Acta Psychiatr Scand, 85(6), 474–479. https://doi.org/10.1111/j.1600-0447.1992.tb03214.x
Shah, S. A., P. M. Doraiswamy, M. M. Husain, P. R. Escalona, C. Na, G. S. Figiel, L. J. Patterson, E. H. Ellinwood, W. M. McDonald, and O. B. Boyko. “Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study.Acta Psychiatr Scand 85, no. 6 (June 1992): 474–79. https://doi.org/10.1111/j.1600-0447.1992.tb03214.x.
Shah SA, Doraiswamy PM, Husain MM, Escalona PR, Na C, Figiel GS, et al. Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study. Acta Psychiatr Scand. 1992 Jun;85(6):474–9.
Shah, S. A., et al. “Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study.Acta Psychiatr Scand, vol. 85, no. 6, June 1992, pp. 474–79. Pubmed, doi:10.1111/j.1600-0447.1992.tb03214.x.
Shah SA, Doraiswamy PM, Husain MM, Escalona PR, Na C, Figiel GS, Patterson LJ, Ellinwood EH, McDonald WM, Boyko OB. Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study. Acta Psychiatr Scand. 1992 Jun;85(6):474–479.
Journal cover image

Published In

Acta Psychiatr Scand

DOI

ISSN

0001-690X

Publication Date

June 1992

Volume

85

Issue

6

Start / End Page

474 / 479

Location

United States

Related Subject Headings

  • Psychiatry
  • Pons
  • Neurocognitive Disorders
  • Middle Aged
  • Medulla Oblongata
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Depressive Disorder