Cognitive performance on the Alzheimer's Disease Assessment Scale: effect of education.


Journal Article

The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used to monitor disease progression and treatment efficacy in clinical trials of Alzheimer's disease (AD). Using data from a 12-week drug trial, we retrospectively studied the effect of education on ADAS-Cog performance in a group of 444 patients with AD. The effect of education was statistically significant on baseline ADAS-Cog total scores. This effect remained statistically significant after controlling for age, gender, and dementia severity. Education effects were also statistically significant at week 12 for ADAS-Cog total and 10 of 11 subitem scores in 138 AD patients in the placebo arm of the trial. Post hoc analysis showed that non-high school graduates performed worse than those with greater educational levels across a broad range of cognitive domains. Our results, in conjunction with reports linking lower educational level with a higher risk for AD, suggest that educational level of patients be given consideration in the design and interpretation of cognitive tests in AD drug trials.

Full Text

Duke Authors

Cited Authors

  • Doraiswamy, PM; Krishen, A; Stallone, F; Martin, WL; Potts, NL; Metz, A; DeVeaugh-Geiss, J

Published Date

  • November 1995

Published In

Volume / Issue

  • 45 / 11

Start / End Page

  • 1980 - 1984

PubMed ID

  • 7501145

Pubmed Central ID

  • 7501145

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.45.11.1980


  • eng

Conference Location

  • United States