Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.


Journal Article

We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free platelet [3H]-imipramine binding and brain MRI studies were obtained during the same episode of depression. Our findings show a significant inverse relationship between frequency of subcortical hyperintensity (SCH) and the number (Bmax) of platelet [3H]-imipramine binding sites. Patients with Bmax less than 850 fmol/mg protein had significantly larger SCH compared with patients with a higher Bmax. These data provide further support to the potential use of platelet [3H]-imipramine binding studies and brain MR imaging as diagnostic adjuncts in geriatric depression and suggest, moreover, that these two biological markers may be linked in geriatric patients with depression.

Full Text

Duke Authors

Cited Authors

  • Husain, MM; Knight, DL; Doraiswamy, PM; Figiel, GS; McDonald, WM; Boyko, OB; Krishnan, KR; Nemeroff, CB

Published Date

  • April 1, 1991

Published In

Volume / Issue

  • 29 / 7

Start / End Page

  • 665 - 670

PubMed ID

  • 1647227

Pubmed Central ID

  • 1647227

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(91)90136-a


  • eng

Conference Location

  • United States