Pituitary size in depression.

Journal Article (Journal Article)

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Doraiswamy, PM; Lurie, SN; Figiel, GS; Husain, MM; Boyko, OB; Ellinwood, EH; Nemeroff, CB

Published Date

  • February 1991

Published In

Volume / Issue

  • 72 / 2

Start / End Page

  • 256 - 259

PubMed ID

  • 1991797

International Standard Serial Number (ISSN)

  • 0021-972X

Digital Object Identifier (DOI)

  • 10.1210/jcem-72-2-256


  • eng

Conference Location

  • United States