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Assessment of posterior fossa structures with midsagittal MRI: the effects of age.

Publication ,  Journal Article
Shah, SA; Doraiswamy, PM; Husain, MM; Figiel, GS; Boyko, OB; McDonald, WM; Ellinwood, EH; Krishnan, KR
Published in: Neurobiol Aging
1991

Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p less than 0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p less than 0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.

Duke Scholars

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1991

Volume

12

Issue

4

Start / End Page

371 / 374

Location

United States

Related Subject Headings

  • Sex Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cranial Fossa, Posterior
  • Aging
  • Aged
 

Citation

APA
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ICMJE
MLA
NLM
Shah, S. A., Doraiswamy, P. M., Husain, M. M., Figiel, G. S., Boyko, O. B., McDonald, W. M., … Krishnan, K. R. (1991). Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging, 12(4), 371–374. https://doi.org/10.1016/0197-4580(91)90025-f
Shah, S. A., P. M. Doraiswamy, M. M. Husain, G. S. Figiel, O. B. Boyko, W. M. McDonald, E. H. Ellinwood, and K. R. Krishnan. “Assessment of posterior fossa structures with midsagittal MRI: the effects of age.Neurobiol Aging 12, no. 4 (1991): 371–74. https://doi.org/10.1016/0197-4580(91)90025-f.
Shah SA, Doraiswamy PM, Husain MM, Figiel GS, Boyko OB, McDonald WM, et al. Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging. 1991;12(4):371–4.
Shah, S. A., et al. “Assessment of posterior fossa structures with midsagittal MRI: the effects of age.Neurobiol Aging, vol. 12, no. 4, 1991, pp. 371–74. Pubmed, doi:10.1016/0197-4580(91)90025-f.
Shah SA, Doraiswamy PM, Husain MM, Figiel GS, Boyko OB, McDonald WM, Ellinwood EH, Krishnan KR. Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging. 1991;12(4):371–374.
Journal cover image

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1991

Volume

12

Issue

4

Start / End Page

371 / 374

Location

United States

Related Subject Headings

  • Sex Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cranial Fossa, Posterior
  • Aging
  • Aged