Assessment of posterior fossa structures with midsagittal MRI: the effects of age.
Publication
, Journal Article
Shah, SA; Doraiswamy, PM; Husain, MM; Figiel, GS; Boyko, OB; McDonald, WM; Ellinwood, EH; Krishnan, KR
Published in: Neurobiol Aging
1991
Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p less than 0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p less than 0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.
Duke Scholars
Published In
Neurobiol Aging
DOI
ISSN
0197-4580
Publication Date
1991
Volume
12
Issue
4
Start / End Page
371 / 374
Location
United States
Related Subject Headings
- Sex Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Humans
- Female
- Cranial Fossa, Posterior
- Aging
- Aged
Citation
APA
Chicago
ICMJE
MLA
NLM
Shah, S. A., Doraiswamy, P. M., Husain, M. M., Figiel, G. S., Boyko, O. B., McDonald, W. M., … Krishnan, K. R. (1991). Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging, 12(4), 371–374. https://doi.org/10.1016/0197-4580(91)90025-f
Shah, S. A., P. M. Doraiswamy, M. M. Husain, G. S. Figiel, O. B. Boyko, W. M. McDonald, E. H. Ellinwood, and K. R. Krishnan. “Assessment of posterior fossa structures with midsagittal MRI: the effects of age.” Neurobiol Aging 12, no. 4 (1991): 371–74. https://doi.org/10.1016/0197-4580(91)90025-f.
Shah SA, Doraiswamy PM, Husain MM, Figiel GS, Boyko OB, McDonald WM, et al. Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging. 1991;12(4):371–4.
Shah, S. A., et al. “Assessment of posterior fossa structures with midsagittal MRI: the effects of age.” Neurobiol Aging, vol. 12, no. 4, 1991, pp. 371–74. Pubmed, doi:10.1016/0197-4580(91)90025-f.
Shah SA, Doraiswamy PM, Husain MM, Figiel GS, Boyko OB, McDonald WM, Ellinwood EH, Krishnan KR. Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging. 1991;12(4):371–374.
Published In
Neurobiol Aging
DOI
ISSN
0197-4580
Publication Date
1991
Volume
12
Issue
4
Start / End Page
371 / 374
Location
United States
Related Subject Headings
- Sex Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Humans
- Female
- Cranial Fossa, Posterior
- Aging
- Aged