Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2.

Published

Journal Article

Mf2 (mesoderm/mesenchyme forkhead 2) encodes a forkhead/winged helix transcription factor expressed in numerous tissues of the mouse embryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous system, and developing kidney. We have generated mice homozygous for a null mutation in the Mf2 gene (Mf2(lacZ)) to examine its role during embryonic development. The lacZ allele also allows monitoring of Mf2 gene expression. Homozygous null mutants are viable and fertile and have no major developmental defects. Some mutants show renal abnormalities, including kidney hypoplasia and hydroureter, but the penetrance of this phenotype is only 40% or lower, depending on the genetic background. These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes.

Full Text

Duke Authors

Cited Authors

  • Kume, T; Deng, K; Hogan, BL

Published Date

  • February 2000

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 1419 - 1425

PubMed ID

  • 10648626

Pubmed Central ID

  • 10648626

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.20.4.1419-1425.2000

Language

  • eng

Conference Location

  • United States