Out of Eden: stem cells and their niches.
Journal Article (Journal Article;Review)
Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.
Full Text
Duke Authors
Cited Authors
- Watt, FM; Hogan, BL
Published Date
- February 25, 2000
Published In
Volume / Issue
- 287 / 5457
Start / End Page
- 1427 - 1430
PubMed ID
- 10688781
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.287.5457.1427
Language
- eng
Conference Location
- United States