Out of Eden: stem cells and their niches.

Journal Article (Journal Article;Review)

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

Full Text

Duke Authors

Cited Authors

  • Watt, FM; Hogan, BL

Published Date

  • February 25, 2000

Published In

Volume / Issue

  • 287 / 5457

Start / End Page

  • 1427 - 1430

PubMed ID

  • 10688781

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.287.5457.1427


  • eng

Conference Location

  • United States