Out of Eden: stem cells and their niches.
Publication
, Journal Article
Watt, FM; Hogan, BL
Published in: Science
February 25, 2000
Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
February 25, 2000
Volume
287
Issue
5457
Start / End Page
1427 / 1430
Location
United States
Related Subject Headings
- Transcription Factors
- Stem Cells
- Proteins
- Integrins
- Humans
- Homeostasis
- General Science & Technology
- Extracellular Matrix
- Cell Lineage
- Cell Division
Citation
APA
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ICMJE
MLA
NLM
Watt, F. M., & Hogan, B. L. (2000). Out of Eden: stem cells and their niches. Science, 287(5457), 1427–1430. https://doi.org/10.1126/science.287.5457.1427
Watt, F. M., and B. L. Hogan. “Out of Eden: stem cells and their niches.” Science 287, no. 5457 (February 25, 2000): 1427–30. https://doi.org/10.1126/science.287.5457.1427.
Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science. 2000 Feb 25;287(5457):1427–30.
Watt, F. M., and B. L. Hogan. “Out of Eden: stem cells and their niches.” Science, vol. 287, no. 5457, Feb. 2000, pp. 1427–30. Pubmed, doi:10.1126/science.287.5457.1427.
Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science. 2000 Feb 25;287(5457):1427–1430.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
February 25, 2000
Volume
287
Issue
5457
Start / End Page
1427 / 1430
Location
United States
Related Subject Headings
- Transcription Factors
- Stem Cells
- Proteins
- Integrins
- Humans
- Homeostasis
- General Science & Technology
- Extracellular Matrix
- Cell Lineage
- Cell Division