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Transcription of H-2 and Qa genes in embryonic and adult mice.

Publication ,  Journal Article
Fahrner, K; Hogan, BL; Flavell, RA
Published in: EMBO J
May 1987

We have isolated cDNAs for three class I genes from an 8.5-day C57Bl/6 mouse embryo cDNA library. Two of these cDNAs encode the classical transplantation antigens, H-2Kb and H-2Db. The third is a novelly spliced form of a Qa region gene, Q9, which lacks several exons including that encoding the transmembrane domain. Since this mRNA is detected on membrane-bound polysomes it may encode a secreted protein. Transcripts for these three genes and the pseudo-allele of Q9, Q7, were present at very low levels in the 8.5-day and 14.5-day embryo and in the 2-day neonate, compared to most adult tissues. Q10, the liver-specific secreted class I gene product in adults, is preferentially expressed in yolk sac and in fetal liver. We found no embryo-specific class I gene expression.

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Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

May 1987

Volume

6

Issue

5

Start / End Page

1265 / 1271

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Tissue Distribution
  • Mice, Inbred C57BL
  • Mice
  • Major Histocompatibility Complex
  • L Cells
  • Introns
  • Histocompatibility Antigens Class I
  • H-2 Antigens
  • Genes
 

Citation

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Fahrner, K., Hogan, B. L., & Flavell, R. A. (1987). Transcription of H-2 and Qa genes in embryonic and adult mice. EMBO J, 6(5), 1265–1271. https://doi.org/10.1002/j.1460-2075.1987.tb02363.x
Fahrner, K., B. L. Hogan, and R. A. Flavell. “Transcription of H-2 and Qa genes in embryonic and adult mice.EMBO J 6, no. 5 (May 1987): 1265–71. https://doi.org/10.1002/j.1460-2075.1987.tb02363.x.
Fahrner K, Hogan BL, Flavell RA. Transcription of H-2 and Qa genes in embryonic and adult mice. EMBO J. 1987 May;6(5):1265–71.
Fahrner, K., et al. “Transcription of H-2 and Qa genes in embryonic and adult mice.EMBO J, vol. 6, no. 5, May 1987, pp. 1265–71. Pubmed, doi:10.1002/j.1460-2075.1987.tb02363.x.
Fahrner K, Hogan BL, Flavell RA. Transcription of H-2 and Qa genes in embryonic and adult mice. EMBO J. 1987 May;6(5):1265–1271.

Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

May 1987

Volume

6

Issue

5

Start / End Page

1265 / 1271

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Tissue Distribution
  • Mice, Inbred C57BL
  • Mice
  • Major Histocompatibility Complex
  • L Cells
  • Introns
  • Histocompatibility Antigens Class I
  • H-2 Antigens
  • Genes