Organogenesis: molecular mechanisms of tubulogenesis.

Journal Article (Journal Article;Review)

As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behaviour, including cell polarization, tube migration to target sites, cell-fate diversification and localization of specialized cells to different regions of the tube system. Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.

Full Text

Duke Authors

Cited Authors

  • Hogan, BLM; Kolodziej, PA

Published Date

  • July 2002

Published In

Volume / Issue

  • 3 / 7

Start / End Page

  • 513 - 523

PubMed ID

  • 12094229

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg840


  • eng

Conference Location

  • England