Location of the gene involving the small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2).

Published

Journal Article

Using an interspecific backcross, we have mapped the gene involved in the mouse Small eye mutation (SeyMH) relative to six cloned markers on chromosome 2 (Hox-5.1, Cas-1, Fshb, Bmp-2a, and ld) and the agouti locus. The results suggest that the Sey gene maps between Fshb and Cas-1. Human mapping studies have shown that the aniridia (AN2) gene, which is part of the Wilms tumor susceptibility, aniridia, genitourinary abnormalities, and mental retardation (WAGR) complex, is also between FSHB and CAT on human chromosome 11. The conserved linkage of the cloned markers and the similarity of the Sey/+ and AN2/+ phenotypes suggest that the gene involved in the Sey mutation is the mouse homolog of the human AN2 gene.

Full Text

Duke Authors

Cited Authors

  • van der Meer-de Jong, R; Dickinson, ME; Woychik, RP; Stubbs, L; Hetherington, C; Hogan, BL

Published Date

  • June 1, 1990

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 270 - 275

PubMed ID

  • 2347591

Pubmed Central ID

  • 2347591

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(90)90550-e

Language

  • eng

Conference Location

  • United States