Localization of the mouse gene for secreted phosphoprotein 1 (Spp-1) (2ar, osteopontin, bone sialoprotein 1, 44-kDa bone phosphoprotein, tumor-secreted phosphoprotein) to chromosome 5, closely linked to Ric (Rickettsia resistance).
Journal Article (Journal Article)
We have used a cDNA probe for mouse secreted phosphoprotein 1 (Spp-1, also known as 2ar, osteopontin, bone sialoprotein 1, 44-kDa bone phosphotein, tumor-secreted protein) to find a restriction fragment length polymorphism in the gene from C57BL/6J and DBA/2J mice. The strain distribution pattern in 25 BXD recombinant inbred lines is identical with that previously determined for the dominant, autosomal gene, Ricr (Rickettsia resistance). This places Spp-1 on mouse chromosome 5 with a 95% confidence limit of being within 4.32 cM of Ric. Evidence supporting the possibility of allelism between Spp-1 and Ric is briefly discussed.
Full Text
Duke Authors
Cited Authors
- Fet, V; Dickinson, ME; Hogan, BL
Published Date
- August 1, 1989
Published In
Volume / Issue
- 5 / 2
Start / End Page
- 375 - 377
PubMed ID
- 2571582
International Standard Serial Number (ISSN)
- 0888-7543
Digital Object Identifier (DOI)
- 10.1016/0888-7543(89)90074-8
Language
- eng
Conference Location
- United States