Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation.

Journal Article (Journal Article)

Transforming growth factor beta 1 (TGF beta 1) has been shown to have multiple effects on primary cultures of palate-derived cell types. We report the analysis, by in situ hybridization, of RNA expression for three different TGF beta isoforms (TGF beta 1, beta 2, and beta 3) during murine embryonic palate development. Differential expression of the three TGF beta genes is seen in the palatal shelves in mesenchymal and epithelial cells known to be involved in the morphogenesis of this organ. Taken together, these results suggest that the TGF beta s act as endogenous factors involved in the formation of the mammalian palate.

Full Text

Duke Authors

Cited Authors

  • Pelton, RW; Hogan, BL; Miller, DA; Moses, HL

Published Date

  • October 1990

Published In

Volume / Issue

  • 141 / 2

Start / End Page

  • 456 - 460

PubMed ID

  • 1698672

International Standard Serial Number (ISSN)

  • 0012-1606

Digital Object Identifier (DOI)

  • 10.1016/0012-1606(90)90401-4


  • eng

Conference Location

  • United States