Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation.
Journal Article (Journal Article)
Transforming growth factor beta 1 (TGF beta 1) has been shown to have multiple effects on primary cultures of palate-derived cell types. We report the analysis, by in situ hybridization, of RNA expression for three different TGF beta isoforms (TGF beta 1, beta 2, and beta 3) during murine embryonic palate development. Differential expression of the three TGF beta genes is seen in the palatal shelves in mesenchymal and epithelial cells known to be involved in the morphogenesis of this organ. Taken together, these results suggest that the TGF beta s act as endogenous factors involved in the formation of the mammalian palate.
- Pelton, RW; Hogan, BL; Miller, DA; Moses, HL
- October 1990
Volume / Issue
- 141 / 2
Start / End Page
- 456 - 460
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States