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In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2.

Publication ,  Journal Article
Pelton, RW; Dickinson, ME; Moses, HL; Hogan, BL
Published in: Development
October 1990

To date, three closely-related TGF beta genes have been found in the mouse; TGF beta 1, TGF beta 2 and TGF beta 3. Previous experiments have indicated that TGF beta 1 and TGF beta 2 may play important roles during mouse embryogenesis. The present study now reports the distribution of transcripts of TGF beta 3 in comparison to the other two genes and reveals overlapping but distinct patterns of RNA expression. TGF beta 3 RNA is expressed in a diverse array of tissues including perichondrium, bone, intervertebral discs, mesenteries, pleura, heart, lung, palate, and amnion, as well as in central nervous system (CNS) structures such as the meninges, choroid plexus and the olfactory bulbs. Furthermore, in several organ systems, TGF beta 3 transcripts are expressed during periods of active morphogenesis suggesting that the protein may be an important factor for the growth and differentiation of many embryonic tissues.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

October 1990

Volume

110

Issue

2

Start / End Page

609 / 620

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • RNA
  • Nucleic Acid Hybridization
  • Morphogenesis
  • Mice
  • Gene Expression
  • Embryo, Mammalian
  • DNA Probes
  • Animals
  • 42 Health sciences
 

Citation

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ICMJE
MLA
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Pelton, R. W., Dickinson, M. E., Moses, H. L., & Hogan, B. L. (1990). In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development, 110(2), 609–620. https://doi.org/10.1242/dev.110.2.609
Pelton, R. W., M. E. Dickinson, H. L. Moses, and B. L. Hogan. “In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2.Development 110, no. 2 (October 1990): 609–20. https://doi.org/10.1242/dev.110.2.609.
Pelton, R. W., et al. “In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2.Development, vol. 110, no. 2, Oct. 1990, pp. 609–20. Pubmed, doi:10.1242/dev.110.2.609.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

October 1990

Volume

110

Issue

2

Start / End Page

609 / 620

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • RNA
  • Nucleic Acid Hybridization
  • Morphogenesis
  • Mice
  • Gene Expression
  • Embryo, Mammalian
  • DNA Probes
  • Animals
  • 42 Health sciences