A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.
Journal Article (Journal Article)
The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGF beta superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGF beta signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGF beta signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis.
Full Text
Duke Authors
Cited Authors
- Weisberg, E; Winnier, GE; Chen, X; Farnsworth, CL; Hogan, BL; Whitman, M
Published Date
- December 1998
Published In
Volume / Issue
- 79 / 1-2
Start / End Page
- 17 - 27
PubMed ID
- 10349617
International Standard Serial Number (ISSN)
- 0925-4773
Digital Object Identifier (DOI)
- 10.1016/s0925-4773(98)00160-9
Language
- eng
Conference Location
- Ireland