Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine.
Journal Article (Journal Article)
We have identified and characterized the phenotype of a new insertional mutation in one line of transgenic mice. Mice carrying this mutation, which we have designated TgN(Imusd)370Rpw, display undulations of the vertebrae giving rise to a novel kinky-tail phenotype. Molecular characterization of the insertion site indicates that the transgene integration has occurred without any substantial alterations in the structure of the host sequences. Using probes that flank the insertion site, we have mapped the mutation to chromosome 5 near the semidominant mutation, thick tail (Tht). Thick tail does not complement the TgN(Imusd)370Rpw mutation; compound mutants containing one copy of each mutation display a more severe phenotype than either mutation individually.
Full Text
Duke Authors
Cited Authors
- Schrick, JJ; Dickinson, ME; Hogan, BL; Selby, PB; Woychik, RP
Published Date
- July 1995
Published In
Volume / Issue
- 140 / 3
Start / End Page
- 1061 - 1067
PubMed ID
- 7672577
Pubmed Central ID
- PMC1206661
International Standard Serial Number (ISSN)
- 0016-6731
Digital Object Identifier (DOI)
- 10.1093/genetics/140.3.1061
Language
- eng
Conference Location
- United States