Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities.
Publication
, Journal Article
Hogan, BL; Hirst, EM; Horsburgh, G; Hetherington, CM
Published in: Development
1988
Small eye (Sey) is a dominant mutation in the mouse affecting the embryonic development of the eyes and nose. In homozygous Sey/Sey embryos, the optic vesicles grow out but there is no lens induction and the nasal pits fail to develop. Scanning electron microscope studies of Sey/Sey embryos show that the maxillary processes develop normally and fuse with ridges of ectoderm in the frontonasal position. In Sey/+ heterozygotes, the vacuolated lens is smaller than normal, and there is folding of the margins of the optic cup and ingrowth of mesodermal cells. Evidence is presented that Sey is not allelic with Coloboma (Cm), another mutation affecting eye development on chromosome 2.
Duke Scholars
Published In
Development
DOI
ISSN
0950-1991
Publication Date
1988
Volume
103 Suppl
Start / End Page
115 / 119
Location
England
Related Subject Headings
- Phenotype
- Models, Genetic
- Microscopy, Electron, Scanning
- Mice, Mutant Strains
- Mice
- Eye
- Embryo, Mammalian
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Hogan, B. L., Hirst, E. M., Horsburgh, G., & Hetherington, C. M. (1988). Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities. Development, 103 Suppl, 115–119. https://doi.org/10.1242/dev.103.Supplement.115
Hogan, B. L., E. M. Hirst, G. Horsburgh, and C. M. Hetherington. “Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities.” Development 103 Suppl (1988): 115–19. https://doi.org/10.1242/dev.103.Supplement.115.
Hogan BL, Hirst EM, Horsburgh G, Hetherington CM. Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities. Development. 1988;103 Suppl:115–9.
Hogan, B. L., et al. “Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities.” Development, vol. 103 Suppl, 1988, pp. 115–19. Pubmed, doi:10.1242/dev.103.Supplement.115.
Hogan BL, Hirst EM, Horsburgh G, Hetherington CM. Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities. Development. 1988;103 Suppl:115–119.
Published In
Development
DOI
ISSN
0950-1991
Publication Date
1988
Volume
103 Suppl
Start / End Page
115 / 119
Location
England
Related Subject Headings
- Phenotype
- Models, Genetic
- Microscopy, Electron, Scanning
- Mice, Mutant Strains
- Mice
- Eye
- Embryo, Mammalian
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences