Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.

Journal Article (Journal Article)

We have cloned a mouse cDNA encoding a Mothers-against-dpp (MAD)-related protein, MADR1. Madr1 is ubiquitously expressed in the mouse embryo, indicating a broad function in a variety of tissue during embryogenesis, potentially relaying signals of numerous BMPs. However, its expression in the testis is strictly germ cell-specific and developmentally regulated. Testicular Madr1 expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty, a stage-specific Madr1 expression is established. During the cycling of the seminiferous epithelium, Madr1 expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids. In the testis of adult Bmp8b homozygous mutant males, the Madr1- expressing pachytene spermatocytes are the first cell population to show increased apoptosis. These data suggest that MADR1 serves as a downstream component of the BMP8 signaling pathway during the differentiation of meiotic male germ cells.

Full Text

Duke Authors

Cited Authors

  • Zhao, GQ; Hogan, BL

Published Date

  • January 1997

Published In

Volume / Issue

  • 61 / 1-2

Start / End Page

  • 63 - 73

PubMed ID

  • 9076678

International Standard Serial Number (ISSN)

  • 0925-4773

Digital Object Identifier (DOI)

  • 10.1016/s0925-4773(96)00622-3


  • eng

Conference Location

  • Ireland