Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.

Journal Article (Journal Article)

There are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-known pressor and mitogenic effects of angiotensin II, but the signalling mechanism and physiological role of AT2 has not been established. Its abundant expression in fetal tissues and certain brain nuclei suggest possible roles in growth, development and neuronal functions. Here we report the unexpected finding that the targeted disruption of the mouse AT2 gene resulted in a significant increase in blood pressure and increased sensitivity to the pressor action of angiotensin II. Thus AT2 mediates a depressor effect and antagonizes the AT1-mediated pressor action of angiotensin II. In addition, disruption of the AT2 gene attenuated exploratory behaviour and lowered body temperature. Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour.

Full Text

Duke Authors

Cited Authors

  • Ichiki, T; Labosky, PA; Shiota, C; Okuyama, S; Imagawa, Y; Fogo, A; Niimura, F; Ichikawa, I; Hogan, BL; Inagami, T

Published Date

  • October 26, 1995

Published In

Volume / Issue

  • 377 / 6551

Start / End Page

  • 748 - 750

PubMed ID

  • 7477267

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/377748a0


  • eng

Conference Location

  • England