The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus.

Published

Journal Article

Two probes derived from a mouse recombinant lambda-clone (H24.1), that contains a sequence closely homologous to the Drosophila antennapedia homeo box, were mapped to mouse chromosome (MMU) 11 by filter hybridization of somatic cell hybrid DNA. This sequence is highly homologous to a human homeo box gene (HOX2) and appears to represent one of the two genes in the Hox-2 cluster previously assigned to MMU 11. To regionally map the Hox-2 cluster, we have carried out in situ hybridization of the two H24.1 probes and of an independently isolated Hox-2 probe. The autoradiographic silver grain distributions were similar in all three experiments with a peak over band 11D. This region contains the locus for the tail-short (Ts) mutation which causes skeletal abnormalities in heterozygotes and early embryonic death in homozygotes.

Full Text

Duke Authors

Cited Authors

  • Münke, M; Cox, DR; Jackson, IJ; Hogan, BL; Francke, U

Published Date

  • 1986

Published In

Volume / Issue

  • 42 / 4

Start / End Page

  • 236 - 240

PubMed ID

  • 2875852

Pubmed Central ID

  • 2875852

International Standard Serial Number (ISSN)

  • 0301-0171

Digital Object Identifier (DOI)

  • 10.1159/000132284

Language

  • eng

Conference Location

  • Switzerland