The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus.
Journal Article (Journal Article)
Two probes derived from a mouse recombinant lambda-clone (H24.1), that contains a sequence closely homologous to the Drosophila antennapedia homeo box, were mapped to mouse chromosome (MMU) 11 by filter hybridization of somatic cell hybrid DNA. This sequence is highly homologous to a human homeo box gene (HOX2) and appears to represent one of the two genes in the Hox-2 cluster previously assigned to MMU 11. To regionally map the Hox-2 cluster, we have carried out in situ hybridization of the two H24.1 probes and of an independently isolated Hox-2 probe. The autoradiographic silver grain distributions were similar in all three experiments with a peak over band 11D. This region contains the locus for the tail-short (Ts) mutation which causes skeletal abnormalities in heterozygotes and early embryonic death in homozygotes.
Full Text
Duke Authors
Cited Authors
- Münke, M; Cox, DR; Jackson, IJ; Hogan, BL; Francke, U
Published Date
- 1986
Published In
Volume / Issue
- 42 / 4
Start / End Page
- 236 - 240
PubMed ID
- 2875852
International Standard Serial Number (ISSN)
- 0301-0171
Digital Object Identifier (DOI)
- 10.1159/000132284
Language
- eng
Conference Location
- Switzerland