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Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family.

Publication ,  Journal Article
Jones, CM; Simon-Chazottes, D; Guenet, JL; Hogan, BL
Published in: Mol Endocrinol
November 1992

A cDNA clone, Vgr-2, with homology to certain members of the transforming growth factor-beta superfamily has been isolated from a mouse embryo cDNA library. The encoded protein shows significant similarity to members of the Vg-1/decapentaplegic/bone morphogenetic protein subgroup of the transforming growth factor-beta family. Within this group, Vgr-2 is more similar to Xenopus Vg-1 than to any other member so far isolated. The gene is expressed at highest levels during midgestation mouse development, and transcripts are localized by in situ hybridization to the osteogenic zone of developing bone. Vgr-2 is expressed in F9 teratocarcinoma cells, and its RNA levels are down-regulated within 24 h after differentiation with retinoic acid. The genomic organization of Vgr-2 and its location on mouse chromosome 6 are reported.

Duke Scholars

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

November 1992

Volume

6

Issue

11

Start / End Page

1961 / 1968

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factor beta
  • Teratoma
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Proteins
  • Multigene Family
  • Molecular Sequence Data
  • Mice
  • Insect Hormones
 

Citation

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Jones, C. M., Simon-Chazottes, D., Guenet, J. L., & Hogan, B. L. (1992). Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol, 6(11), 1961–1968. https://doi.org/10.1210/mend.6.11.1480182
Jones, C. M., D. Simon-Chazottes, J. L. Guenet, and B. L. Hogan. “Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family.Mol Endocrinol 6, no. 11 (November 1992): 1961–68. https://doi.org/10.1210/mend.6.11.1480182.
Jones CM, Simon-Chazottes D, Guenet JL, Hogan BL. Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol. 1992 Nov;6(11):1961–8.
Jones, C. M., et al. “Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family.Mol Endocrinol, vol. 6, no. 11, Nov. 1992, pp. 1961–68. Pubmed, doi:10.1210/mend.6.11.1480182.
Jones CM, Simon-Chazottes D, Guenet JL, Hogan BL. Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol. 1992 Nov;6(11):1961–1968.

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

November 1992

Volume

6

Issue

11

Start / End Page

1961 / 1968

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factor beta
  • Teratoma
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Proteins
  • Multigene Family
  • Molecular Sequence Data
  • Mice
  • Insect Hormones