Gelation of liposome interior. A novel method for drug encapsulation.
Journal Article (Journal Article)
Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy, and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.
Full Text
Duke Authors
Cited Authors
- Lasic, DD; Frederik, PM; Stuart, MC; Barenholz, Y; McIntosh, TJ
Published Date
- November 9, 1992
Published In
Volume / Issue
- 312 / 2-3
Start / End Page
- 255 - 258
PubMed ID
- 1426260
International Standard Serial Number (ISSN)
- 0014-5793
Digital Object Identifier (DOI)
- 10.1016/0014-5793(92)80947-f
Language
- eng
Conference Location
- England