Gelation of liposome interior. A novel method for drug encapsulation.

Journal Article (Journal Article)

Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy, and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.

Full Text

Duke Authors

Cited Authors

  • Lasic, DD; Frederik, PM; Stuart, MC; Barenholz, Y; McIntosh, TJ

Published Date

  • November 9, 1992

Published In

Volume / Issue

  • 312 / 2-3

Start / End Page

  • 255 - 258

PubMed ID

  • 1426260

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(92)80947-f

Language

  • eng

Conference Location

  • England