Alamethicin-induced changes in lipid bilayer morphology.

Journal Article (Journal Article)

We have found that alamethicin, in the absence of an electric field, modifies both the hydrophilic surface and hydrophobic core of lipid bilayers. As shown by freeze-fracture and X-ray diffraction experiments with multiwalled vesicles, alamethicin increases the fluid space between bilayers by as much as 50 nm, and at the same time perturbs the hydrocarbon regions of the bilayers. For suspensions of gel-state lipid treated with alamethicin, uniformly spaced rows of particles cover the fracture faces and corresponding linear arrays of stain-collecting depressions cover the hydrophilic surfaces. In the liquid-crystalline state, alamethicin induces an irregular granular texture on the fracture faces.

Full Text

Duke Authors

Cited Authors

  • McIntosh, TJ; Ting-Beall, HP; Zampighi, G

Published Date

  • February 8, 1982

Published In

Volume / Issue

  • 685 / 1

Start / End Page

  • 51 - 60

PubMed ID

  • 7059590

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/0005-2736(82)90034-7


  • eng

Conference Location

  • Netherlands