Handedness of crossover connections in beta sheets.

Journal Article (Journal Article)

In a crossover connection, the polypeptide chain leaves one end of a beta sheet, forms a loop of any length and any conformation, and reenters the same beta sheet from the opposite end. Of the 85 examples of crossover connections which occur in the known protein structures, 83 are righthanded and only two are lefthanded. It is proposed that consistent handedness, even in long irregular loops, could be produced by the preferred twist direction of extended chain and the righthandedness of alpha-helices, provided certain conditions hold during the protein folding process.

Full Text

Duke Authors

Cited Authors

  • Richardson, JS

Published Date

  • August 1976

Published In

Volume / Issue

  • 73 / 8

Start / End Page

  • 2619 - 2623

PubMed ID

  • 183204

Pubmed Central ID

  • PMC430699

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.73.8.2619


  • eng

Conference Location

  • United States