Amino acid preferences for specific locations at the ends of alpha helices.

Journal Article (Journal Article)

A definition based on alpha-carbon positions and a sample of 215 alpha helices from 45 different globular protein structures were used to tabulate amino acid preferences for 16 individual positions relative to the helix ends. The interface residue, which is half in and half out of the helix, is called the N-cap or C-cap, whichever is appropriate. The results confirm earlier observations, such as asymmetrical charge distributions in the first and last helical turn, but several new, sharp preferences are found as well. The most striking of these are a 3.5:1 preference for Asn at the N-cap position, and a preference of 2.6:1 for Pro at N-cap + 1. The C-cap position is overwhelmingly dominated by Gly, which ends 34 percent of the helices. Hydrophobic residues peak at positions N-cap + 4 and C-cap - 4.

Full Text

Duke Authors

Cited Authors

  • Richardson, JS; Richardson, DC

Published Date

  • June 17, 1988

Published In

Volume / Issue

  • 240 / 4859

Start / End Page

  • 1648 - 1652

PubMed ID

  • 3381086

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3381086


  • eng

Conference Location

  • United States