Iodine-123-4-amino-3-iodobenzylguanidine, a new sympathoadrenal imaging agent: comparison with iodine-123 metaiodobenzylguanidine.

Published

Journal Article

Iodine-123-4-amino-3-iodobenzylguanidine ([123I]AIBG), an analog of 123I metaiodobenzylguanidine ([123I]MIBG), has an advantage in having a more rapid and simple synthesis. This, combined with animal data that suggested a greater affinity of the new radiopharmaceutical for the autonomic innervation of the myocardium led us to study the biodistribution of [123I]AIBG in three men with metastatic pheochromocytoma. In all instances, [123I]AIBG revealed the same metastatic deposits shown by [123I]MIBG. Iodine-123 AIBG uptake, however, was greater than [123I]MIBG in lung, gut, and spleen. These higher backgrounds may pose diagnostic problems in some cases.

Full Text

Duke Authors

Cited Authors

  • Shulkin, BL; Shapiro, B; Tobes, MC; Shen, SW; Wieland, DM; Meyers, LJ; Lee, HT; Petry, NA; Sisson, JC; Beierwaltes, WH

Published Date

  • July 1, 1986

Published In

Volume / Issue

  • 27 / 7

Start / End Page

  • 1138 - 1142

PubMed ID

  • 3723189

Pubmed Central ID

  • 3723189

Electronic International Standard Serial Number (EISSN)

  • 1535-5667

International Standard Serial Number (ISSN)

  • 0161-5505

Language

  • eng