Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial blood flow.

Journal Article

SQ30217 is a new, technetium-99m-(99mTc) labeled perfusion agent introduced for cardiac imaging. To evaluate the myocardial tracer kinetics, 99mTc-SQ30217, was injected intracoronarily in open-chested dogs under baseline conditions and after administration of intravenous (i.v.) dipyridamole. Myocardial first-pass retention fraction averaged 0.90 +/- 0.04. Clearance of the tracer occurred in a biexponential manner. Sixty-seven percent of retained activity cleared with a half-time of 2.3 +/- 0.6 min, while the residual activity demonstrated slow clearance. The clearance rate of the rapid phase correlated with myocardial blood flow (r = 0.72, p less than 0.001). Myocardial SQ30217 clearance rate following i.v. injection as determined by dynamic imaging with tomography (SPRINT) averaged 21 +/- 4 min and increased to 13 +/- 4 min following dipyridamole. Thus, 99mTc-SQ30217 is a promising flow tracer with high initial myocardial retention and rapid tissue clearance, which allow repeated flow determinations within short time intervals using advanced SPECT technology.

Full Text

Duke Authors

Cited Authors

  • Stewart, RE; Schwaiger, M; Hutchins, GD; Chiao, PC; Gallagher, KP; Nguyen, N; Petry, NA; Rogers, WL

Published Date

  • July 1, 1990

Published In

Volume / Issue

  • 31 / 7

Start / End Page

  • 1183 - 1190

PubMed ID

  • 2362197

International Standard Serial Number (ISSN)

  • 0161-5505

Language

  • eng

Conference Location

  • United States