Requirement of MIP-1 alpha for an inflammatory response to viral infection.
Journal Article (Journal Article)
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.
Full Text
Duke Authors
Cited Authors
- Cook, DN; Beck, MA; Coffman, TM; Kirby, SL; Sheridan, JF; Pragnell, IB; Smithies, O
Published Date
- September 15, 1995
Published In
Volume / Issue
- 269 / 5230
Start / End Page
- 1583 - 1585
PubMed ID
- 7667639
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.7667639
Language
- eng
Conference Location
- United States