Skip to main content
Journal cover image

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

Publication ,  Journal Article
Cook, DN; Beck, MA; Coffman, TM; Kirby, SL; Sheridan, JF; Pragnell, IB; Smithies, O
Published in: Science
September 15, 1995

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science

DOI

ISSN

0036-8075

Publication Date

September 15, 1995

Volume

269

Issue

5230

Start / End Page

1583 / 1585

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Stem Cells
  • Orthomyxoviridae Infections
  • Neutralization Tests
  • Myocarditis
  • Monokines
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
  • Macrophage Inflammatory Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cook, D. N., Beck, M. A., Coffman, T. M., Kirby, S. L., Sheridan, J. F., Pragnell, I. B., & Smithies, O. (1995). Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science, 269(5230), 1583–1585. https://doi.org/10.1126/science.7667639
Cook, D. N., M. A. Beck, T. M. Coffman, S. L. Kirby, J. F. Sheridan, I. B. Pragnell, and O. Smithies. “Requirement of MIP-1 alpha for an inflammatory response to viral infection.Science 269, no. 5230 (September 15, 1995): 1583–85. https://doi.org/10.1126/science.7667639.
Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, et al. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583–5.
Cook, D. N., et al. “Requirement of MIP-1 alpha for an inflammatory response to viral infection.Science, vol. 269, no. 5230, Sept. 1995, pp. 1583–85. Pubmed, doi:10.1126/science.7667639.
Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, Smithies O. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583–1585.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

September 15, 1995

Volume

269

Issue

5230

Start / End Page

1583 / 1585

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Stem Cells
  • Orthomyxoviridae Infections
  • Neutralization Tests
  • Myocarditis
  • Monokines
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
  • Macrophage Inflammatory Proteins