Requirement of MIP-1 alpha for an inflammatory response to viral infection.

Journal Article (Journal Article)

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

Full Text

Duke Authors

Cited Authors

  • Cook, DN; Beck, MA; Coffman, TM; Kirby, SL; Sheridan, JF; Pragnell, IB; Smithies, O

Published Date

  • September 15, 1995

Published In

Volume / Issue

  • 269 / 5230

Start / End Page

  • 1583 - 1585

PubMed ID

  • 7667639

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7667639


  • eng

Conference Location

  • United States