Angiotensin-II-receptors: new targets for antihypertensive therapy.

Journal Article (Journal Article;Review)

The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation of this system is implicated in the pathogenesis of various forms of hypertension. Traditional therapy for hypertension has included angiotensin-converting enzyme inhibitors, which block the production of AII. However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.

Full Text

Duke Authors

Cited Authors

  • Oliverio, MI; Coffman, TM

Published Date

  • January 1997

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 3 - 6

PubMed ID

  • 8994730

Pubmed Central ID

  • PMC6655881

International Standard Serial Number (ISSN)

  • 0160-9289

Digital Object Identifier (DOI)

  • 10.1002/clc.4960200103


  • eng

Conference Location

  • United States