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Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.

Publication ,  Journal Article
Audoly, LP; Oliverio, MI; Coffman, TM
Published in: Trends Endocrinol Metab
September 2000

The renin-angiotensin system (RAS) has a wide range of actions in biological processes ranging from development and reproduction to cardiovascular and renal functions. Most of these actions are mediated by the octapeptide hormone angiotensin II. The identified family of angiotensin II receptors is divided into two pharmacological classes: type 1 (AT1) and type 2 (AT2). The classically recognized actions of the RAS are primarily mediated by the AT1 subtype of angiotensin receptors, and these receptors are the targets of a new class of anti-hypertensive agents. In recent years, our understanding of the physiological functions of AT1 receptors has been advanced through the use of gene-targeting technology. In this review, we will summarize the emerging picture of AT1 receptor functions that has been provided by gene-targeting experiments.

Duke Scholars

Published In

Trends Endocrinol Metab

DOI

ISSN

1043-2760

Publication Date

September 2000

Volume

11

Issue

7

Start / End Page

263 / 269

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Immunity
  • Humans
  • Gene Targeting
  • Endocrinology & Metabolism
  • Blood Pressure
  • Animals
 

Citation

APA
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ICMJE
MLA
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Audoly, L. P., Oliverio, M. I., & Coffman, T. M. (2000). Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting. Trends Endocrinol Metab, 11(7), 263–269. https://doi.org/10.1016/s1043-2760(00)00279-4
Audoly, L. P., M. I. Oliverio, and T. M. Coffman. “Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.Trends Endocrinol Metab 11, no. 7 (September 2000): 263–69. https://doi.org/10.1016/s1043-2760(00)00279-4.
Audoly LP, Oliverio MI, Coffman TM. Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting. Trends Endocrinol Metab. 2000 Sep;11(7):263–9.
Audoly, L. P., et al. “Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.Trends Endocrinol Metab, vol. 11, no. 7, Sept. 2000, pp. 263–69. Pubmed, doi:10.1016/s1043-2760(00)00279-4.
Audoly LP, Oliverio MI, Coffman TM. Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting. Trends Endocrinol Metab. 2000 Sep;11(7):263–269.
Journal cover image

Published In

Trends Endocrinol Metab

DOI

ISSN

1043-2760

Publication Date

September 2000

Volume

11

Issue

7

Start / End Page

263 / 269

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Immunity
  • Humans
  • Gene Targeting
  • Endocrinology & Metabolism
  • Blood Pressure
  • Animals