What can knockout mice contribute to an understanding of hypertension?

Journal Article (Journal Article;Review)

The generation of knockout mice using homologous recombination in embryonic stem cells is a powerful tool for physiologic investigations. This experimental approach has provided unique insights into the study of hypertension. Studies using knockout mice have shed new light on blood pressure regulatory mechanisms, molecular mechanisms of end-organ injury, and genetic mechanisms for hypertension. With the development of more accessible approaches for carrying out sophisticated manipulation of the mouse genome, there will be continuing utility of this technique for future studies of hypertension.

Full Text

Duke Authors

Cited Authors

  • Audoly, LP; Le, TH; Coffman, TM

Published Date

  • April 2000

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 192 - 197

PubMed ID

  • 10981148

International Standard Serial Number (ISSN)

  • 1522-6417

Digital Object Identifier (DOI)

  • 10.1007/s11906-000-0081-4


  • eng

Conference Location

  • United States