What can knockout mice contribute to an understanding of hypertension?
Journal Article (Journal Article;Review)
The generation of knockout mice using homologous recombination in embryonic stem cells is a powerful tool for physiologic investigations. This experimental approach has provided unique insights into the study of hypertension. Studies using knockout mice have shed new light on blood pressure regulatory mechanisms, molecular mechanisms of end-organ injury, and genetic mechanisms for hypertension. With the development of more accessible approaches for carrying out sophisticated manipulation of the mouse genome, there will be continuing utility of this technique for future studies of hypertension.
Full Text
Duke Authors
Cited Authors
- Audoly, LP; Le, TH; Coffman, TM
Published Date
- April 2000
Published In
Volume / Issue
- 2 / 2
Start / End Page
- 192 - 197
PubMed ID
- 10981148
International Standard Serial Number (ISSN)
- 1522-6417
Digital Object Identifier (DOI)
- 10.1007/s11906-000-0081-4
Language
- eng
Conference Location
- United States