Evidence that ribavirin is transported in Aedes albopictus cells by the nucleoside transport system.

Published

Journal Article

Aedes albopictus cells (CAE-3-6) deficient in the transport of nucleosides showed a markedly impaired ability to transport the antiviral compound, ribavirin. Furthermore, in order to inhibit either cell growth or viral replication, the transport negative CAE-3-6 cells required significantly higher concentrations of ribavirin than were needed for a similar degree of inhibition in the parental C7 cells. Although ribavirin did lower the level of GTP in CAE-3-6 cells the effect was slower and less striking than in the parental cells. These results indicate that ribavirin is transported across the plasma membrane of Aedes albopictus cells by the same transport system which functions to transport naturally occurring nucleosides.

Full Text

Duke Authors

Cited Authors

  • Sherwood, A; Stollar, V

Published Date

  • December 1984

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 317 - 324

PubMed ID

  • 6532319

Pubmed Central ID

  • 6532319

Electronic International Standard Serial Number (EISSN)

  • 1872-9096

International Standard Serial Number (ISSN)

  • 0166-3542

Digital Object Identifier (DOI)

  • 10.1016/0166-3542(84)90002-0

Language

  • eng