Identification of a fetal exon in the human fast troponin T gene.

Journal Article (Journal Article)

A developmentally regulated exon has been identified in the 5'-alternatively spliced region of the human fast Troponin T (TnT) gene. Expressed in fetal (but not adult) muscle, this exon is homologous with the fetal exons recently described in the rabbit and rat fast TnT genes. They all exhibit a split codon organization and encode a highly acidic peptide. To determine if the splicing pathways, including the human fetal exon, are also conserved, we defined the major TnT splicing patterns in fetal muscle. They generate fetal TnT 1, fetal TnT 3, and TnT1f, and TnT3f, species previously described in rabbit and rat skeletal muscles.

Full Text

Duke Authors

Cited Authors

  • Briggs, MM; Maready, M; Schmidt, JM; Schachat, F

Published Date

  • August 15, 1994

Published In

Volume / Issue

  • 350 / 1

Start / End Page

  • 37 - 40

PubMed ID

  • 8062920

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(94)00729-2


  • eng

Conference Location

  • England