Early gene changes in myocardial ischemia.
Journal Article (Journal Article)
After certain periods of myocardial ischemia and reperfusion, cardiac dysfunction exists in the absence of myonecrosis. In a blood-perfused isolated rat heart model, we have demonstrated early gene changes that are associated with global myocardial "stunning." Early gene changes included elevations in the expression of messenger RNAs for HSP70, c-myc and c-fos. Increased expression of messenger RNAs for protooncogenes is an important observation because of the role of protooncogenes as nuclear transcription factors. From these study findings, it would appear that the stunning state is associated with early gene changes that may signal the induction of a hypertrophic process. Subsequent studies are required to demonstrate the exact events which take place in the course of stunning that directly initiate an alteration in gene expression.
Full Text
Duke Authors
Cited Authors
- Wechsler, AS; Entwistle, JC; Yeh, T; Ding, M; Jakoi, ER
Published Date
- October 1994
Published In
Volume / Issue
- 58 / 4
Start / End Page
- 1282 - 1284
PubMed ID
- 7944806
Pubmed Central ID
- 7944806
International Standard Serial Number (ISSN)
- 0003-4975
Digital Object Identifier (DOI)
- 10.1016/0003-4975(94)90529-0
Language
- eng
Conference Location
- Netherlands