Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists.

Journal Article (Journal Article;Review)

Platelet glycoprotein (GP) IIb/IIIa receptor antagonists are being used with increasing frequency in the settings of percutaneous coronary interventions and acute ischemic syndromes. The development of bleeding complications following GPIIb/IIIa blockade represents a significant limitation to its effectiveness. Baseline characteristics predictive of future bleeding events in patients receiving platelet GPIIb/IIIa receptor antagonist include older age, low body weight, evolving myocardial infarction, and female sex. In patients undergoing percutaneous coronary interventions with adjunctive GPIIb/IIIa inhibition, the risk of bleeding, particularly from the femoral vascular access site, may be reduced through the use of low-dose, weight-adjusted heparin (70 U/kg), avoidance of postprocedural heparin, and early vascular sheath removal. Strategies to reduce the incidence of bleeding complications in patients receiving GPIIb/IIIa inhibitors are proposed in this article.

Full Text

Duke Authors

Cited Authors

  • Madan, M; Blankenship, JC; Berkowitz, SD

Published Date

  • September 1999

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 334 - 341

PubMed ID

  • 10468150

International Standard Serial Number (ISSN)

  • 1065-6251

Digital Object Identifier (DOI)

  • 10.1097/00062752-199909000-00011


  • eng

Conference Location

  • United States